1A2-D08 高温ポストキュア処理によるマイクロ光造形樹脂の細胞適合化メカニズムの解明(ナノ・マイクロバイオシステム)

概要

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Microstereolithgraphy was one of the 3D micro fabrication methods to make arbitrary 3d structures. But photo curable polymers using in conventional stereolithography did not have biocompatibility. To overcome this problem, we've already reported that high temperature postbake process gave photo curable polymer cytocompatibility. In this report, stereolithographic objects with transparency and cytocompatibility were accomplished by the high temperature heat process in nitrogen atmosphere. By using MTT assay, almost same cytocompatibility of the postbeked photo curable polymer compared with a commercial cell culture dishes was verified. And our result indicated that cytoxicity of photo curable polymer was reduced due to sublimation and diffusion of cytotoxic substance from cured photo curable polymer. The new post-bake process should be a fundamental technology for future development of biological and medical micromachines.
一般社団法人日本機械学会の論文
2011-05-26