過剰塩分摂取が腎機能低下を呈する一般住民の血中B型利尿ペプチドに及ぼす影響の検討

概要

論文の詳細を見る
Background: Both subtle elevation of B-type natriuretic peptide (BNP) and a decrease in estimated glomerular filtration ratio (eGFR) were reported to be related to the development of cardiovascular disease in apparently asymptomatic populations. However, the relationship between excess salt intake, eGFR and BNP in the general population remains to be determined.Methods and Results: This community-based cross sectional study enrolled individuals over 40 years old (n = 3115) in Takahata, Japan. There were 206 subjects with chronic kidney disease (CKD) (eGFR < 60 mL/min/1.73m2). Plasma BNP levels were higher in subjects with CKD than in those without CKD. However, subjects with CKD had a lower salt intake, higher systolic blood pressure and higher plasma renin activity (PRA) than subjects without CKD. There was a greater increase in BNP levels with salt intake in CKD subjects compared to those without CKD. PRA was significantly suppressed by excess salt intake in both groups. Multivariate analysis showed that salt intake was an independent risk factor for elevated BNP levels in CKD subjects, but not in those without CKD.Conclusions: Excess salt intake is an independent risk factor for elevated plasma BNP levels, especially in subjects with CKD. These results suggest that sodium restriction for prevention of future cardiovascular events may be more important in subjects with CKD than in those without CKD.
2014-02-15