シトクロムP450 4F2の遺伝子多型 : 血清ビタミンE濃度,ワルファリン感受性および高血圧症との関連(<特集>「ビタミンと遺伝子多型」-ビタミンE-)

概要

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Cytochrome P450 (CYP) 4F2 was identified as a leukotriene B_4 ω-hydroxylase, and is responsible for hepatic ω-hydroxylation of vitamin E and vitamin K_1, and renal production of 20-hydroxyeicosatetraenoic acid (20-HETE), a vasoconstrictor and natriuretic substance. Single nucleotide polymorphism (SNP) rs2108622 is a missense mutation, V433M, in CYP4F2 gene, which is of considerable clinical importance. CYP4F2 V433M polymorphism reduces production of hydroxytocopherol, hydroxyphylloquinone, and 20-HETE in vitro. SNP rs2108622 was associated with serum α-tocopherol, but not γ-tocopherol concentration, in two genome-wide association study cohorts and interindividual variability in response to coumarin drugs in systematic review and meta-analysis. The SNP also was associated with systolic and diastolic blood pressure and incident ischemic stroke in men, but not in women, in a large cohort study.
2013-07-25