Custom Synthesis of Hyaluronan/Chondroitin Sulfate Hybrid Oligosaccharides : For Future Medical Applications
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概要
- 論文の詳細を見る
Hyaluronan and chondroitin sulfate sugar chains play important roles as major components of extracellular matrix. They are attractive molecules for biochemical research and are also used in pharmaceutical agents. However, details of the relationships between their oligosaccharide structures and functions are not known because of a lack of availability of model oligosaccharides with known structures. In order to, in the future, investigate their functions based on structure, we synthesized hybrid oligosaccharides by the in vitro transglycosylation reaction of hyaluronidase using various combinations of acceptors and donors. A total of 18 kinds of pyridylaminated hyaluronan/chondroitin sulfate hybrid oligosaccharides （from octasaccahride to dodecasaccharide）, which have not been found in nature, were synthesized.
- 弘前大学の論文
- 2013-00-00
著者
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Kakizaki Ikuko
Department Of Biochemistry Hirosaki University School Of Medicine
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Endo Masahiko
Department Of Biochemistry School Of Medicine Hirosaki University
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Tatara Yota
Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine
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Suto Shinichiro
Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine
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Endo Masahiko
Department of Glycotechnology, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine
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