Positive Therapeutic Response to Bevacizumab Plus Paclitaxel in a Patient with Advanced, Life-Threatening Breast Cancer and Carcinomatous Lymphangitis:a Subsequent Treatment Change to Hormone Therapy
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概要
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We present a case of advanced, life-threatening breast cancer with carcinomatous lymphangitis treatedwith bevacizumab plus paclitaxel. A positive therapeutic response was achieved and the treatment was subsequentlychanged to hormone therapy.The patient was a 53-year-old postmenopausal woman with a non-contributory medical history. She presentedto a nearby hospital with chief complaints of continued exertional dyspnea and coughing since March2012. Physical findings included a palpable mass in the left breast, and the patient was referred and presentedto our hospital in May. Examinations at our hospital revealed left-sided breast cancer (estrogen receptorpositive, progesterone receptor positive, and no amplification of the human epidermal growth factorreceptor 2 by FISH). The patient had bone metastasis and carcinomatous lymphangitis (cT2N3cM1-stageIV). The condition was life threatening, and administration of bevacizumab plus weekly paclitaxel was initiatedwith the expectation of a high response rate. Coughing and dyspnea resolved two weeks later. CTscans were taken in August after the completion of 3 cycles and showed improvement in carcinomatouslymphangitis. No major side effects were observed due to bevacizumab plus weekly paclitaxel. When theCT scans were taken in December after the completion of 6 cycles, the primary lesion and lymph node metastaseswere reduced in size. In the lung field, there was no thickening of the interlobular septa or subpleuralinterstitium, and the findings of carcinomatous lymphangitis were improved. Thus, bevacizumab plus paclitaxelwere discontinued and the treatment was changed to oral letrozole (2.5 mg/day). The patient hasbeen followed up with no recurrence as of March 2013.
- 2013-07-25
著者
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Kawashima Miho
Department Of Radiology And Radiation Oncology Gunma University School Of Medicine
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Nozaki Miwako
Deparment Of Radiology Dokkyo University School Of Medicine Koshigaya Hospital
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Ueda Yoshihiko
Department Of Pathology Dokkyo Medical University Koshigaya Hospital
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Yamagishi Hidetsugu
Department of Gastroenterology, Dokkyo Medical University School of Medicine
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Oya Masatoshi
Breast Center, Dokkyo Medical University Koshigaya Hospital
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Ishizuna Kazuo
Breast Center, Dokkyo Medical University Koshigaya Hospital
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Ninomiya Jun
Ninomiya Hospital
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Kojima Makoto
Breast Center, Dokkyo Medical University Koshigaya Hospital
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Nishibayashi Fumiko
Department of Radiology, Dokkyo Medical University Kosigaya Hospital
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Nozaki Miwako
Department of Radiology, Dokkyo Medical University Kosigaya Hospital
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Kawashima Miho
Department of Radiology, Dokkyo Medical University Kosigaya Hospital
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Ueda Yoshihiko
Department of Pathology, Dokkyo Medical University Kosigaya Hospital
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