PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE IS AN ESSENTIAL REGULATOR OF LYSOSOME MORPHOLOGY
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概要
- 論文の詳細を見る
Phosphoinositides are lipid second messengers that act as key players in endosomal membrane trafficking, and mutations in several phosphatases that metabolize these lipids cause severe genetic diseases. We previously reported that type III phosphatidylinositol phosphate kinase (PIPKIII) is a critical regulator of lysosome size. However, the lipid products that mediate PIPKIII function have not been well characterized. Using a series of phosphoinositide phosphatase expression vectors, we show here that phosphatidylinositol 3,5-bisphosphate is the obligatory lipid for lysosome morphology.
- 2013-03-00
著者
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Sasaki Junko
Department Of Biotechnology Kyoto Sangyo University
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Sasaki Takehiko
Department Of Biomolecular Medicine Akita Graduate University School Of Medicine
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Takasuga Shunsuke
Department of Medical Biology, Akita University Graduate School of Medicine
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Asanuma Ken
Department of Medical Biology, Akita University Graduate School of Medicine
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