The Physiology of Phosphoinositides(Metabolism and Functions of Phosphoinositides)

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概要

• 論文の詳細を見る

• Phosphoinositides are a family of phosphorylated derivatives of the membrane lipid phosphatidylinositol. These lipids are highly concentrated in distinct pools located in a cell's plasma membrane, endosomes or nucleus, where they function as ligands for phosphoinositide-binding proteins. Protein domains that bind phosphoinositides include the pleckstrin homology (PH) domain, the phox homology (PX) domain and the Fablp-YOPB-Vps27p-EEA1 (FYVE) domain. These domains are found in many proteins involved in intracellular signaling, membrane trafficking and cytoskeletal rearrangement. Recent studies have identified potential links between alterations to various signaling pathways involving phosphoinositides and the etiology of many human diseases.

• 2007-09-01

著者

• SASAKI Takehiko

  Department of Neurosurgery, Nakamura Memorial Hospital

• SASAKI Junko

  Department of Microbiology, Akita University School of Medicine

• SUZUKI Akira

  Division of Embryonic and Genetic Engineering Medical Institute of Bioregulation, Kyushu University

• Sakai Takahiro

  Department Of Organic And Polymeric Materials Tokyo Institute Of Technology

• Sasaki J

  Department Of Microbiology Akita University School Of Medicine

• Sasaki Junko

  Division Of Functional Genomics Department Of Post-genomics And Diseases Osaka University Graduate S

• Sasaki Takehiko

  Department Of Microbiology Akita University School Of Medicine

• TAKASUGA Shunsuke

  Department of Pathology and Immunology, Division of Microbiology, Akita University School of Medicin

• Sasaki Junko

  Department Of Biotechnology Kyoto Sangyo University

• Takasuga Shunsuke

  Department Of Pathology And Immunology Division Of Microbiology Akita University School Of Medicine

• Sasaki Takehiko

  Department Of Complexity Science And Engineering Graduate School Of Frontier Sciences The University

• Sakai Takahiro

  Department Of Pathology And Immunology Division Of Microbiology Akita University School Of Medicine

• Sakai Takahiro

  Department Of Bioscience And Biotechnology Faculty Of Engineering Okayama University

• Suzuki Akira

  Division Of Embryonic And Genetic Engineering Medical Institute Of Bioregulation Kyushu University

• Sasaki Takehiko

  Department Of Biomolecular Medicine Akita Graduate University School Of Medicine

• Suzuki Akira

  Division Of Blood Transfusion Tohoku University Hospital

• Takasuga Shunsuke

  Department of Medical Biology, Akita University Graduate School of Medicine

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