反鼻の薬理学的研究(第3報) : 反鼻の急性毒性,循環器系に対する作用およびその他の作用

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A water extract (HW) of Agkistrodon Japonicae, "Hampi," was tested in mice for its acute toxicity and the effects on cardiovascular and central nervous systems and analgesic and anti-inflammatory actions. The acute toxicity of HW was very low. However such acute symptoms as sedation, shortening of pupil and palpebral opening were observed in mice. The administration of HW intravenously produced transient hypotensive action in both anesthetized rats and rabbits, and increase of dermal blood flow in the inner surface of rabbit ear and of liver blood flow in anesthetized rabbits were observed. HW was also found to depress spontaneous motor activity, to tend to increase analgesic index in tail pressure method in mice and to suppress ultraviolet erythema in guinea pigs.
1986-06-20