Finding Conserved Regions in Protein Structures Using Support Vector Machines and Structure Alignment
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概要
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In this technical report, we propose a novel method for finding conserved regions in three-dimensional protein structures, which combines support vector machines (SVMs), feature selection and protein structure alignment. For that purpose, a new feature vector is developed based on structure alignment for fragments of protein backbone structures. The results of preliminary computational experiments suggest that the proposed method is useful to find common structural fragments in similar proteins.
- 2012-10-08
著者
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Tatsuya Akutsu
Bioinformatics Center, Institute for Chemical Research, Kyoto University
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Morihiro Hayashida
Bioinformatics Center Institute For Chemical Research Kyoto University
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Takeyuki Tamura
Bioinformatics Center Institute For Chemical Research Kyoto Univerty
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Tatsuya Akutsu
Bioinformatics Center Institute For Chemical Research Kyoto University
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Tatsuya Akutsu
Bioinformatics Center Institute For Chemical Research Kyoto Univerty
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Takeyuki Tamura
Bioinformatics Center Institute For Chemical Research Kyoto University
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