Efficient Computation of Impact Degrees for Multiple Reactions in Metabolic Networks with Cycles
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概要
- 論文の詳細を見る
Analysis of the robustness of a metabolic network against deletion of single or multiple reaction(s) is useful for mining important enzymes/genes. For that purpose, the impact degree was proposed by Jiang et al. In this article, we extend the impact degree for metabolic networks containing cycles and develop a simple algorithm for its computation. Furthermore, we propose an improved algorithm for computing impact degrees for deletions of multiple reactions. The results of preliminary computational experiments suggest that the improved algorithm is several tens of times faster than a simple algorithm.
- 一般社団法人情報処理学会の論文
- 2009-09-10
著者
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Tatsuya Akutsu
Bioinformatics Center, Institute for Chemical Research, Kyoto University
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Ching Wai-ki
Department Of Mathematics The University Of Hong Kong
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Takeyuki Tamura
Bioinformatics Center Institute For Chemical Research Kyoto Univerty
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Tatsuya Akutsu
Bioinformatics Center Institute For Chemical Research Kyoto University
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Tatsuya Akutsu
Bioinformatics Center Institute For Chemical Research Kyoto Univerty
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Yang Cong
Department of Mathematics, The University of Hong Kong
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Yang Cong
Department Of Mathematics The University Of Hong Kong
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Takeyuki Tamura
Bioinformatics Center Institute For Chemical Research Kyoto University
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