Investigation of the antiviral properties of copper iodide nanoparticles against feline calicivirus(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
スポンサーリンク
概要
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This study demonstrated the antiviral properties of copper iodide (Cul) nanoparticles against the non-enveloped virus feline calicivirus (FCV) as a surrogate for human norovirus. The effect of Cul nanoparticles on FCV infectivity to Crandell-Rees feline kidney (CRFK) cells was elucidated. The infectivity of FCV to CRFK cells was greatly reduced by 7 orders of magnitude at 1000 μg ml^<-1> Cul nanoparticles. At the conditions, electron spin resonance (ESR) analysis proved hydroxyl radical production in Cul nanoparticle suspension. Furthermore, amino acid oxidation in the viral capsid protein of FCV was determined by nanoflow liquid chromatography-mass spectrometric (nano LC-MS) analysis. The use of Cul nanoparticles showed extremely high antiviral activity against FCV. The high antiviral property of Cul nanoparticles was attributed to Cu^+, followed by ROS generation and subsequent capsid protein oxidation. Cul nanoparticles could be proposed as useful sources of a continuous supply of Cu^+ ions for efficient virus inactivation. Furthermore, this study brings new insights into toxic actions of copper iodide nanoparticles against viruses.
著者
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TANAKA TSUYOSHI
Division of Earth and Environmental Sciences, Nagoya University
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SATO TETSUYA
Division for Space Propulsion, The Institute of Space and Astronautical Science
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Matsunaga Tadashi
Division Of Biotechnology And Life Science Institute Of Engineering Tokyo University Of Agriculture And Technology
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Shionoiri Nozomi
Division of Biotechnology and Life Science, Institute of Engineering, Tokyo University of Agriculture and Technology
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Fujimoto Yoshie
NBC Meshtec Inc.
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Nakayama Tsuruo
NBC Meshtec Inc.
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Nemoto Michiko
Division of Biotechnology and Life Science, Institute of Engineering, Tokyo University of Agriculture and Technology
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Nemoto Michiko
Division Of Biotechnology And Life Science Institute Of Engineering Tokyo University Of Agriculture And Technology
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Shionoiri Nozomi
Division Of Biotechnology And Life Science Institute Of Engineering Tokyo University Of Agriculture And Technology
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Tanaka Tsuyoshi
Division Of Biotechnology And Life Science Institute Of Engineering Tokyo University Of Agriculture And Technology
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FUJIMORI Yoshie
NBC Meshtec Inc.
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Sato Tetsuya
Division Of Biotechnology And Life Science Institute Of Engineering Tokyo University Of Agriculture And Technology
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