Immunosuppressive drug rapamycin restores sporulation competence in industrial yeasts(BREWING AND FOOD TECHNOLOGY)
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概要
- 論文の詳細を見る
Industrial yeasts, including a sake yeast strain Kyokai no. 7 (K7), are generally unable to sporulate. Previously, we have reported that in K7 (Saccharomyces cerevisiae) cells, deletion of the G1 cyclin gene CLN3, a key activator of the cell cycle, allows the cells to induce IME1 transcription and sporulate under sporulation conditions. Here we show that treatment with the immunosuppressive drug rapamycin also restores sporulation competence in K7 cells. Moreover, sporulation was observed after rapamycin treatment in other industrial yeasts, namely bottom fermenting yeast strains and a wine yeast strain, which are not able to sporulate under normal sporulation conditions. These findings suggest that activation of TORC1 under sporulation conditions leads to sporulation incompetence in these yeasts. Thus, rapamycin treatment will be useful to restore sporulation competence in industrial yeasts.
- 公益社団法人日本生物工学会の論文
著者
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Nakazawa Nobushige
Department Of Biotechnology Faculty Of Bioresource Science Akita Prefectural University
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Ito Toshihiko
Department Of Neuropsychiatry School Of Medicine Chiba University Department Of Physiology School Of
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Tanaka Yukari
Department Of Biotechnology Faculty Of Bioresource Science Akita Prefectural University
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Niijima Seiko
Department of Biotechnology, Faculty of Bioresource Science, Akita Prefectural University
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Niijima Seiko
Department Of Biotechnology Faculty Of Bioresource Science Akita Prefectural University
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Ito Toshihiko
Department Of Biotechnology Faculty Of Bioresource Science Akita Prefectural University
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Nakazawa Nobushige
Department Of Applied Biology Faculty Of Bioresource Sciences Akita Prefectural University
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Ito Toshihiko
Department Of Biological Resource Science Akita Prefectural University
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