Studies on Mode of Inhibitory Effects of Tetramethylpyrazine and Ferulic Acid on Spontaneous Movement of Rat Uterus in situ

概要

論文の詳細を見る
We reported that tetramethylpyrazine and ferulic acid inhibited spontaneous uterine contractions in rats in situ and the inhibitory effect induced by the combination of the two compounds was potentialize effect. The present work was carried out to study the mode of the inhibitory action of tetramethylpyrazine and ferulic acid on spontaneous uterine contractions in rats in situ. The inhibitory effect induced by tetramethylpyrazine was blocked by propranolol, but not by cimetidine, and the inhibitory effect was produced also in reserpinized rats. Tetramethylpyrazine slightly inhibited the 5-hydroxytryptamine- or oxytocin-induced uterine contractions but scarcely the acetylcholine-induced contraction. The inhibitory effect induced by ferulic acid was blocked neither by propranolol nor by cimetidine. Ferulic acid inhibited the oxytocin-induced uterine contraction strongly, but not the acetylcholine- or 5-hydroxytryptamine-induced contraction. Indomethacin did not affect the inhibitory effects induced by tetramethylpyrazine and ferulic acid. The fallowings were suggested: 1; tetramethylpyrazine mainly acts on the β-adrenoceptor directly and ferulic acid partly on the oxytocin-receptor system, 2; neither of the inhibitory effects induced by the two compounds is due to their inhibitory action on the prostaglandin biosynthesis, 3; since the active sites of the two compounds are different, the effect on rat uterus induced by a combination of tetramethylpyrazine and ferulic acid may be potentialize effect.
日本生薬学会の論文
1991-12-20

Studies on Mode of Inhibitory Effects of Tetramethylpyrazine and Ferulic Acid on Spontaneous Movement of Rat Uterus in situ

スポンサーリンク

概要

著者

関連論文

スポンサーリンク