キンポウゲ科植物に含まれるサイクロアルタン型トリテルペン配糖体に関する研究
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概要
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Triterpene glycosides, containing oleanane-, dammarane- and cycloartane-types, play an important role in the pharmacological activities of medicinal plants. Most available popular crude drugs, Glycyrrhizae Radix, Bupleuri Radix, Puerariae Radix, Ginseng Radix, Astragali Radix and Cimicifugae Rhizoma include the triterpene glycosides. Among these triterpene glycosides, cycloartane-type triterpene has not often been investigated in previous phytochemical investigations. Therefore, I have targeted cycloartane-type triterpene to show its various bioactivities. To develop the research on the bioactive cycloartane glycoside in the ranunculaceous plants, I have investigated the chemical constituents in the genus Thalictrum (T. thunbergii and T. squarrosum) and Aquilegia (A. flabellata and A. vulgaris ) plants, Thalictri Herba and Cimicifugae Rhizoma. As a result, I have isolated thirty new cycloartane glycosides and have evaluated these compounds in mouse allogeneic mixed lymphocyte reaction.
- 日本生薬学会の論文
- 2005-10-20
著者
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