Effects of NK_1 and NMDA Receptor Antagonists on Severe Gagging Induced by Superior Laryngeal Nerve Stimulation in Rats

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概要

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• Severe gagging, which is considered to be one of the emetic responses, prevents food bolus from being lodged in the pharyngo-laryngeal region. Little is known about the neuronal mechanism of severe gagging, because severe gagging is difficult to induce in animal experiments. In a recent study the authors reported that pulse train stimulation of the superior laryngeal nerve (SLN) at high frequency can be used to induce severe gagging in decerebrate rats. The present study was focused on the roles of NK_1 and NMDA receptors in severe gagging and the influence that the receptor antagonists may exert on this process. Intravenous administration of WIN51708, NK_1 receptor antagonist, significantly diminished the probability of the induction of severe gagging elicited by 3 sets of pulse train of the SLN at intervals of 1.7 sec (100Hz, 0.3ms, 50pulses, n=7). Similarly, MK-801, NMDA receptor antagonist, significantly diminished the probability of the induction of severe gagging (n=9). These results suggest that the neural circuits of severe gagging elicited by SLN stimulation could involve both NK_1 and NMDA receptors. Possible action sites of their antagonists in medulla oblongata were discussed and compared with other emetic responses.

• 川崎医療福祉大学の論文

著者

• Koga Tomoshige

  Department Of Physiology Kawasaki Medical School

• Koga Tomoshige

  Department Of Rehabilitation Faculty Of Health Science And Technology Kawasaki University Of Medical

• Yamagata Ryuzo

  Doctoral Program In Rehabilitation Graduate School Of Health Science And Technology Kawasaki University Of Medical Welfare

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• Effects of NK_1 and NMDA Receptor Antagonists on Severe Gagging Induced by Superior Laryngeal Nerve Stimulation in Rats

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