Somatosensory Evoked Potentials in Cerebral Infarction Model Rats Induced by Microsphere Injection to Cerebral Artery

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Microspheres, monodisperse polystyrene beads, are used for the study of cerebral infarction by injection into the cerebral artery. Cerebral infarction model rats were made by injecting 2,600 microspheres into the right internal carotid artery in this study. Motor ability was assessed by the rotarod test in which cling duration on the accelerating rotating rod was measured. Significant decrease in the motor ability was recognized on 3 and 15 days after the embolization compared with before surgery (p<0.05). However, sham-operated rats did not show significant change of motor ability. Each rat was reanaesthetized 15 days after surgery, and somatosensory evoked potentials (SEPs) induced by stimulation of the sciatic nerve of the contralateral hind limb were averaged. Latencies of N_1 and N_2 waves in SEPs were compared between sham-operated rats and embolized rats 15 days after surgery. No significant differences in N_1 and N_2 latencies were recognized between the two groups. These results suggest that motor ability was impaired at chronic periods of the embolization, while SEPs recovered, although latencies of N_1 and N_2 in SEPs were reported to increase at acute periods in embolized rats.
川崎医療福祉大学の論文