肝臓組織の損傷挙動に及ぼす負荷速度の影響

概要

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Effects of loading rate on damage behavior in a pig liver loaded in compression were experimentally investigated. First, we developed a macroscopic damage model of liver cells or hepatocytes. Next, microscopic damage mechanism at the cell level was discussed through in-situ observation. Yield stress and strain were decreased with increasing strain rate. This behavior was ascribed to difference in pressure among individual liver components. The stress in a liver specimen subjected to a constant strain completely disappears after a certain period of time. For low strain rate, all the cells can endure high yield stress and strain because there is enough time for the individual cells to equilibrate the pressure. In contrast, for high strain rate, the yield stress and strain, became lower since the cells cannot equilibrate the pressure due to limited intercellular blood flow during a short time. An interlobular connective tissue (Glisson's sheath) of a hepatic lobule was not easily damaged in the compressive field as it is stronger than the internal tissue. Consequently, the first failure occurred in the weakest central vein.
2010-05-25