気道病態とイオンチャネル(イオンチャネルと病態,シンポジウム,<特集>東京女子医科大学学会第62回総会)

概要

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Increased production of sputum and the difficulty in expectoration are frequently seen in patients with chronic respiratory diseases, but the mechanism of these airway dysfunction remains poorly understood. It has recently been shown that long-term administration of macrolide antibiotics is effective in the treatment of chronic airway infections including diffuse panbronchiolitis, chronic bronchitis and bronchiectasis. Erythromycin causes a remarkable reduction of sputum probably through a mechanism other than its antimicrobial property. To assess whether erythromycin directly inhibits airway secretory responses, we studied bioelectric properties of canine tracheal mucosa under short-circuit condition in vitro and open-circuit condition in vivo. Addition of erythromycin decreased short-circuit current of cultured tracheal epithelial cells and Cl-diffusion potential difference across the tracheal mucosa in a dose-dependent manner. These results suggest that macrolide can inhibit Cl channel opening and subsequent secretion of Cl and water toward the lumen, and that this mechanism may be operating in the efficacy of the drug in patients with aiway hypersecretion.
東京女子医科大学の論文
1997-04-25