新生内膜肥厚モデルにおけるThiazolidine系インスリン感受性 : 改善薬Pioglitazoneの血管保護作用

概要

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It has been demonstrated that thiazolidine, a novel insulin sensitizing agent, has inhibitory effects on the growth of cultured vascular smooth muscle cells (VSMC) in vitro, in addition to its effects on glucose and lipid metabolism. This study was undertaken to examine the in vivo effects of the thiazolidine compound pioglitazone (PIO) on carotid neo-intimal thickening after endothelial injury in Wistar rats. PIO treatment (3mg/kg/day, for 1 week before and 2 weeks after endothelial injury) remarkably decreased neo-intimal cross-section areas (63.8±4.9×10^3μm^2 vs 196±7.6×10^3μm^2 in controls, p<0.05), bromodeoxyuridine uptake in the neo-intima, (as a marker of DNA synthesis), and expression of EIIIA fibronectin as a marker of the synthetic phenotype of VSMC. These results suggest that PIO has direct vasculo-protective effects in acute vascular injury in vivo by inhibition of VSMC proliferation and through phenotypic change of VSMC.
東京女子医科大学の論文
1999-01-25