拡張相肥大型心筋症モデル動物における運動負荷による心筋細胞への影響

概要

論文の詳細を見る
The Bio14.6 strain of cardiomyopathy Syrian hamsters (Bio14.6), which have the 5' deletion of the 8 sarcoglycan gene, has been used as a representative model of human dilated hypertrophic cardiomyopathy (DHCM). We evaluated the influence of exercise on cardiac myocytes in the Bio14.6 at the hypertrophic (23 weeks old) and dilated (41 weeks old) stages. The Bio14.6, and age-matched congenic normal hamsters (CN) as control, were divided into 3 groups: A, swimming in young (3-9 weeks) ; B, swimming in young adults (16～22 weeks); and Cont, sedentary. The results showed that (1) In the 23-week-old hamsters, cardiac hypertrophy had a predominantly greater effect in group A of Bio14.6 (Bio-A) than in any other group. (2) The mRNA expression of the 13-myosin heavy chain in Bio-A surviving until 41 weeks, was 25.7 ± 5.5% which was as low as that observed in the CN groups. (3) Cases of sudden death and of death by congestive heart failure were seen in Bio-A and Bio-B. (4) No relation between the expression of the mRNA of cardiotrophin-1 (CT-1) and clinical phases in Bio14.6 was found. Despite the existence of genetic abnormality, appropriate exercise in the young may play a contributory role to improve the pathogenesis of DHCM.
東京女子医科大学の論文
2000-05-25