大腸癌腫瘍組織内Thymidylate Synthase(TS)の臨床的意義についての検討

概要

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Thymidylate synthase (TS) is one of the essential nuclear enzymes for nucleic acid synthesis, and it is considered to participate in tumor growth. Fluorouracils exert an anti-tumor effect when their products act in conjunction with TS. We herein identified the presence of TS in the cancer cells from 43 patients encountered between 1990 and 1999 with unresectable advanced recurrent colon cancer and who were treated with Leucovorin (LV) /5-fluorouracil (5-FU), using immunostaining techniques with an anti-human recombinant TS polyclonal antibody. The possibility that TS might be a useful indicator of the anti-tumor effect was then assessed based on our results and the patients' clinicopathological factors and prognoses. The staining results were viewed at a magnification of ×200, and the cases were classified into a higher staining-positive-rate group and a lower staining-positive-rate and negative staining group according to the ratio of the number of both tumor cells and positively stained cells. Regarding pathological factors, specimens from patients with deeply invading tumors were frequently classified into the higher staining-positive-rate group. Chemotherapy was often effective in the lower staining-positive-rate group. More favorable outcomes were also obtained in the lower staining-positive-rate group. Fluorouracils therefore appear to effectively treat tumors with lower TS activities.
東京女子医科大学の論文
2002-01-25