ランソプラゾール(タケプロン^[○!R])による薬疹の2例

概要

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We report two cases of drug eruption due to lansoprazole (Takepron^[○!R]). Case 1: A 60-year-old woman was administered amoxicillin (Amolin^[○!R]), clarithromycin (Clarith^[○!R]) and lansoprazole for 1 week as eradication therapy for Helicobacter pylori. Indurated and/or edematous erythemas with severe itching erupted over the patient's entire body the day after the treatment finished. The histopathological findings from the erythema from her abdomen showed an infiltration of lymphocytes around blood vessels in the dermis and epidermis. She also exhibited mild liver dysfunction. The eruptions were almost completely resolved by the following week with antihistamine and steroid ointment therapy. Case 2: An 82-year-old woman was treated with flopropione (Cospanon^[○!R]) and lansoprazole for reflux esophagitis after an operation for stomach cancer. Erythemas, the same as those in case 1, erupted over almost the patient's entire body on the 9th day after the treatment was started. The medicines were discontinued, and we opted to treat her with steroid ointment. The eruptions were almost completely resolved by the following week. Oral provocative tests for lansoprazole were positive in both cases.