STUDIES ON MORPHOLOGICAL CHARACTERISTICS OF MAMMARY ASPIRATION SMEARS

概要

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Morphological characteristics of mammary carcinoma in aspiration cytology were studied. Four items which showed clear differences between malignant and benign specimens were found as follows. 1. Large nucleus; presence of a cell with a nuclear diameter larger than 20 μm in the smear specimen. 2. Large nucleolus; presence of a cell with a nucleolar diameter larger than 5 μm. 3. Marked irregularity in nuclear size; diameter of the largest nucleus in a cell cluster is twice or more that of the smallest nucleus. 4. Increased number of nucleoli; presence of a cell with more than five nucleoli. Specimens in which all 4 items appeared in one smear were recognized only in cancer cases, and those with 3 items in one smear were also found with a high frequency in cancer cases. No items were observed in 91.2% of benign lesions, and 0.72% of cancer cases. Four check items were therefore used for an efficient screening program in aspiration cytology. Cancer cells were also classified into 5 types according to their morphological characteristics. The relationships between the 5 types and 3 known types of common carcinomas, papillary, medullary and scirrhous carcinomas, were discussed.
名古屋市立大学の論文
1981-12-28