SERUM SUCCINYL TRIALANINE p-NITROANILIDE-HYDROLYTIC ACTIVITIES IN WORKERS EXPOSED TO HEAVY METALS

概要

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Succinyl trialanine p-nitroanilide (suc-(Ala)_3-pNA)-hydrolytic enzyme is strongly inhibited by heavy metals such as cadmium and lead. The authors therefore used foundry workers exposed to cadmium contaminations and steel workers exposed to lead in order to survey the effect of these heavy metals on the serum suc-(Ala)_3-pNA-hydrolytic activity, and obtained the following results. 1. Cadmium-exposed workers showed lower suc-(Ala)_3-pNA-hydrolytic activity levels than the controls. The levels were lower in those whose blood cadmium level was high. 2. In the lead-exposed steel workers whose blood lead was at a low concentration, the hydrolytic activity level decreased as the blood lead increased. However, in those with a high blood lead level, the activity level conversely rose as the blood lead increased. These findings indicated that , while cadmium directly inhibited the enzyme and had no other special effects on the enzyme metabolism in the liver, lead might accelerate the enzyme induction or secretion in addition to the direct inhibition of the enzyme. Thus, determination of the enzyme activity can serve as a useful index of health damage in persons contaminated by heavy metals like cadmium or lead.
名古屋市立大学の論文
1982-12-25