IMMUNE COMPLEX AND IMMUNOGLOBURIN IN TOXEMIA OF PREGNANCY

概要

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Serum levels of immune complexes and immunoglobulins were sutudied in normal pregnant women and patient with toxemia of pregnancy. The subjects studied included 15 cases of normal pregnancy and 25 patients with toxemia of pregnancy. The results were as follows: (1) In the third trimester of normal pregnancy, serum levels of immunecomplexes and immunoglobulines were slightly decreased in comparison with healthy non-pregnant women. (2) Patients with toxemia of pregnancy showed a significant increase in the levels of circulating immune complexes but not serum immunoglobulines when compared to women with normal pregnancy of the same gestational age. (3) Only the levels of IgG class were slightly decreased in the severe type of toxemia of pregnancy. The increase of circulating immune complex perhaps induces continuous consumption of complement factors, release of chemotactic factors and anaphylatoxins, and inflammatory reactions in the localized tissues where the complexes precipitate. These results might form a vicious circle with derangements of the regulatory systems which are concerned with metabolism, respiration, circulation, endoxrinium, blood coagulation and fibrinolysis, and thus might cause the syndrome of toxemia of pregnancy.
名古屋市立大学の論文
1983-12-23