TOLBUTAMIDE-STIMULATED RELEASE OF INSULIN WITHOUT PARALLEL INCREASE OF CYCLIC AMP IN A HUMAN BENIGN INSULINOMA

概要

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These release of insulin and glucagon from fragments of a benign human beta islet cell adenoma was assayed by a technique of short-term organ culture. Incubation of the tissue fragments in the presence of 5.6 mM glucose plus 1 mM tolbutamide could not elicit the release of insulin but the content of cyclic AMP significantly increased in the fragments. A higher concentration of glucose (16.7 mM) plus 1 mM tolbutamide raised the release of insulin without any parallel increase of tissue cyclic AMP content. The release of glucagon was minimal under the same conditions and less than that from normal pancreatic tissue. These results suggest that other factors rather than the adenylate cyclase-cyclic AMP system is involved in tolbutamide-mediated secretion of insulin from human pancreatic beta islet cell tumor which we examined.
名古屋市立大学の論文
1984-03-26