乳幼児突然死症候群(SIDS)の病態に関する生理学的検討(特別講演I, 第153回名古屋市立大学医学会例会)

概要

論文の詳細を見る
Sudden Infant Death Syndrome (SIDS) is a leading cause of deaths under one year of age. Polygraphic studies of infnat showed future SIDS victims had more subcortical activations and fewer cortical arousals, an the duration of the subcortical activations was significantly greater in the SIDS than in the control infants, suggesting an incomplete arousal process in infants who eventually died of SIDS. Prone sleep position and maternal smoking are known as risk factors of SIDS. The studies on the frequencies of arousals between prone and supine sleep position were performed using polygraph date of healthy infants. Prone sleep position decreased cortical arousals, but did not change the frequency of subcortical activations as previously seen in SIDS victims. From the studies of the infants with maternal smoking and without maternal smoking, maternal smoking is reported to decrease the arousabilities in infants. These resilts siggest specific pathways for impairment of arousal process in SIDS victims. An insufficient propensity to arouse could lower the chance of infants to survive when exposed to noxious conditions during sleep.
2009-10-01