ASSOCIATION OF DIABETIC NEPHRIPATHY WITH POLYMORPHISMS IN THE ALR2, ACE, eNOS, APOE, AND MYHFR GENES : a JAPANESE EPIDEMIOLOGICAL STUDY

概要

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OBJECTIVE The aim of our study was to evaluate the association of this condition with five candidate gene polymorphisms connected with diabetic nephropathy in diabetic Japanese subjects.RESEACH DESIGN AND METHODS Peripheral blood leukocytes from Japanese diabetic subjects (n=337) with either normoalbuminuria (n=144), microalbuminuria (n=129), proteinuria (n=42), or chronic renal failure (CRF)(n=22) were examined bu the polymerase chain reaction for polymorphisms in the aldose reductase (ALR2), angiotensin-I converting enzyme (ACE) I/D, and apolipoprotein E genes (APOE), as well as for the Glu298Asp mutation in the endothelial nitric oxide synthase (eNOS) gene and the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene.
名古屋市立大学の論文
2009-01-30