リソソーム膜糖タンパク質の細胞内輸送

概要

論文の詳細を見る
Lysosomes are single membrane-bounded vacuoles. A vast number of acid hydrolases in the lysosomal matrix degrades intracellular and extracellular macromolecules such as proteins, polysaccharides, and nucleic acids. The limiting lysosomal membrane contains a set of unique glycoproteins. Significant progress has been made recent years towards elucidating the pathways by which these lysosomal membrane glycoproteins are delivered to lysosomes. While some lysosomal membrane glycoproteins follow the constitutive secretory pathway and reach lysosomes indirectly via the cell surface and endocytosis, others exit the trans-Golgi network for direct delivery to early or late endosomes. Sorting from the Golgi or the plasma membrane into the endosomal system is mediated by signals contained in the short cytoplasmic tail of these membrane proteins. This review discusses the intracellular trafficking of lysosomal membrane glycoproteins, with particular emphasis on the structural features and molecular mechanisms for lysosomal targeting of these glycoproteins.
福山大学の論文