Epinephrine Shockに関する研究 : 第1編 Epinephrine Shock誘発と血漿Ccltecholamine値 : 第2編 GlueoCorticoidによるEpinephrine Shock防止機序 : 第3編心電図変化 : 第4編 Histamine性機序の関与

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Part I. Plasma Catecholamine Level in Epinephrine Shock. In case of intravenous infusion of epinephrine (10 μg/kg/min) shock was induced when the rate of epinephrine removal became limited due to reduction of splanchnic blood flow. Intraportal infusion of epinephrine at the same rate was well tolerated by virtue of the potent hepatic removal of epinephrine. Part II. Mechanism of Protection of Epinephrine Shock by Glucocorticoid. It was shown that glucocorticoid markedly potentiates the hepatic removal of epinephrine. Part III. Electrocardiographic Changes in Epinephrine Shock. In case of epinephrine shock induced by prolonged infusion of epinephrine ventricular arrhythmia and flutter were exceptional. The terminal ECG was characterized by low voltage. Massive accumulation of pericardial effusate was constantly observed. Part IV. Histaminic Mechanism in Epinephrine Shock. Marked histamine release from the liver was observed only in case of epinephrine shock of adrenalectomized dogs. Slight induction of histamine decarboxylase activity could be detected in the liver and serum of shocked dogs.
千葉大学の論文