遊離肺における,肺循環動態の実験的研究 : 主として,実験的拘束性変化にともなう,循環動態について
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Pulmonary vascular resistance was studied, as a function of both transpulmonary pressure (T.P.P.) and lung volume, using left lower lung lobe excised from adult dog, weighing 10-15 kg. The preparations were suspended vertically in a glass-chamber, inflated by negative pressure and per fused by arterial blood, which was introduced in the pulmonary artery by a motor driven syringe at relatively low flow rate, 0.86ml/sec. In some studies excised diaphragm piece wes pasted on costal face or diaphragmatic face of the lower lung lobe and influence of these experimental constriction on the pulmonary vascular resistance and lung volume were examined. 1. In non-constricted lung lobe, pulmonary vascular resistance was found to be lowest at approximately halfly maximal lung volume and showed progressive rise on either further inflation or further deflation ("U-shaped" curve). But these course of resistance was found to be relatively constant when plotted against relative lung volume. Thus vascular resistance during negative-pressure in nonconstricted lung lobe appeared to be "volume dependent". 2. When costal face of left lower lobe was experimentally constricted (ca 50% of lobe surface area), changes of lung volume by negative-pressure inflation was remarkably decreased and maximal lung volume was observed at -20 cmH_2O, T.P.P., corresponding 30% maximal lung volume of non-constricted lung lobe. The course of pulmonary vascular resistance was found to be relatively constant and rectilinear when plotted against negative pressure and minimal value was observed when lung volume reached maximal. Thus vascular resistance during negative-pressure inflation appeared to be pressure dependent rather than volume dependent. These observations suggested the possibility of pressure overloading on inflow side when 50% surface area of left lower lobe was experimentally constricted. 3. The changes of lung volume and course of vascular resistance by negative-pressure inflation, observed when diaphragmatic face was experimentally consticted (30% of lobe surface area), appeared to be intermediate stadium between non-constriction and costalface-constriction.
- 千葉大学の論文
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