遊離肺における,局在性肺循環障害の研究

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A. We used 40 grown-up mongrel dogs, with 6 to 25kgms. body weight, and made to adhere a piece of diaphragm muscle on the rib surface of the visceral pleura at the left lower lobe of the isolated lung and prepared a microconstriction, and then tried a per fusion by connecting with the per fusion device. After the per fusion by blood under negative pressure we washed out erythrocytes using dextran and observed the erythrocytes, which remained in the capillary vessels around the alveolus of lung, by an optical microscope. B. We could hardly recognize erythrocytes in the capillary vessels around the alveolus of the isolated lung under atmospheric pressure, which was decreased by bleeding. And we recognized a distribution of erythrocytes uniformly in the capillary vessels around the alveolus of all over the pulmonary lobe, when blood was per fused at the non constricted lobe of lung under negative pressure inflation. C. In contrast to the fact that we recognized many erythrocytes in the capillary vessels around the alveolus directly under the constricted surface, when blood was per fused at the microconstricted lobe of lung, the distribution of the erythrocytes in the capillary vessels around the alveolus showed a decreasing tendency as they went away from the constricted surface, and after the per fusion, if the blood was washed out using dextran under various negative pressure, no erythrocyte was recognized under a negative pressure condition of -25 cm H_2O neither in the capillary vessels around the alveolus directly under the constricted surface, nor in the capillary vessels around the alveolus of lung, which was not affected by the constriction. On the other hand, after the negative pressure inflation with the per fusion of blood, we made a negative pressure contraction and washed out the per fused blood using dextran at the point of the minimum resistance value of the pulmonary vessels, than we observed that many erythrocytes remained in the capillary vessels around the alveolus directly under the constricted surface, but we could not recognize any erythrocyte in the capillary vessels around the alveolus which was not affected by the constriction. D. We compared the above-mentioned results with many phenomena observed at the per fusion experiments of the lung lobe and made clear the following facts : the vassel resistance value, in the capillary vessels around the alveolus directly under the constricted surface, fell lowest at the maximum negative pressure inflation, and rose gradually at the negative pressure deflation, and at the washing out during deflation the possibility of remaining erythrocytes was found. Therefore, in such conditions of limited stretching restriction (=constriction) or at the limited ventilative obstruction, the local vessel resistance value in that place rose at the negative pressure deflation and the possibility to produce a local disturbance of circulation seems to be shown clearly. We have, then, studied the possibility which shows a prototype of the local disturbances of circulation in the lung in a living body.
千葉大学の論文

遊離肺における,局在性肺循環障害の研究

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