結晶Tetrodotoxinの脊髄反射におよぼす影響について(<特集>脳と神経の研究II)

概要

論文の詳細を見る
The effects of crystalline tetrodotoxin on knee-jerk and flexor reflex in cats were studied. The drug was injected into the lateral cerebral ventricle via a fine polyethylene tube. Both knee-jerk and flexor reflex were increased by a small dose of 0.015μg/kg of tetrodotoxin in the cat lightly anesthetized with chloralose-urethane, while the reflexes were decreased by even the same dose when the animal anesthetized with enough amount of chloralose-urethane. Both reflexes were inhibited, even under light anesthesia, by a large dose of 0.15μg/kg of tetrodotoxin. Electrical stimulation (0.5-1 msec, 30-160/sec, 1-8 V) in the midbrain reticular formation (F. 2.0-3.0, L. 3.0-4.0, V. -1.0--2.0) increased both reflexes, while stimulation in the bulbar reticular formation (P. 10.0, L. 0.5, V. -6.0-- 7.0) decreased them. Tetrodotoxin had no influence on the effects of electrical stimulation of the mid-brain reticular formation, but inhibited the effects of the bulbar reticular formation stimulation.
千葉大学の論文
1965-11-28