腎疾患に於ける水利尿に関する研究 : 稀釈,濃縮力試験に関連して
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概要
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Changes that take place inside the body of an organism in response to changing external conditions should necessarily be confined within certain limits. The kidneys are held mainly responsible for the final phase of the body fluid regulating mechanism which is one of the important factors involved in the maintenance of homeostatic equilibrium. A purpose of the present research is to assess the dilution-concentration test, one of the routine tests for kidney function, correlating it with the renal clearance test, body fluid distribution and electrolytic composition ; another, to investigate how the kidneys serve as part of the water and electrolyte regulating mechanisms in patients with nephritis. It was shown that in persons with stable water and electrolytic balances the results of dilution tests reflected the function of the glomeruli, and those of concentration tests represented the function of the tubules. In patients with nephritis in whom there was increased secretion of the urine following the ingestion of water, the excretion of electrolytes, especially sodium, by the kidneys decreased at the diuresis stage and increased at the concentration stage. As the disturbance of this diuretic faculty intensified, the kidneys tended to lose the faculty of regulating the excretion of electrolytes, especially sodium. There was a specific relation between the degree of disturbance of the faculty of regulating the excretion of sodium and the values of the renal clearance test. The results of the present studies show that the dilution-concentration test for kidney function is of value, for the volume of urine and the amounts of electrolytes, especially sodium, excreted by the kidneys which are to be determined by the test indicate the degree and portion of renal lesion.
- 千葉大学の論文
- 1958-05-28
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- 腎疾患に於ける水利尿に関する研究 : 稀釈,濃縮力試験に関連して