α-[N-(β-diaethylaminoaethyl)]-aminophenylessigsaure-isoamylesterの剔出腸管並びに子宮に対する薬理作用

概要

論文の詳細を見る
Adopon, an autonomic blocking agent which has been synthesized recently in Japan has a chemical structure same as "Avacan" in Germany. A supplementary pharmacological experiment on the mode of action of "Adopon (DAI)" was undertaken on the isolated intestine and uterus of mouse. The results are summarized as follows: 1. The toxcicity of DAI is relatively weak and its LD 50 shows 630 mg/kg subcutaneously. 2. The order of the sensitivity of DAI on isolated intestine is as follows: ileum>coecum>duodenum. The amplitude of the movement of intestine increases markedly and its contraction slightly when DAT is used in small doses. The movement and the tonus of intestine are markedly depressed by administration of medium doses and the movement stops in larger doses of DAI. 3. Any marked change in the tonus of uterus muscle was not observed and the movement of uterus was depressed by using larger doses of DAI. 4. It was observed that DAI antagonized with the action of acetylcholine or histamine and is closely related with antihistamine action. 5. DAI acts on the receptor substance in competition with acetylcholine and blocks the transmission of stimulus.
千葉大学の論文
1954-09-28