histamineによる皮膚毛細血管内皮細胞の墨粒子貧喰能に及ぼす抗histamine剤の影響

概要

論文の詳細を見る
Recently Jansco and Matoltsy, working on the problem of the function of histamine in skin, described that painting of histamine solution on the rat's skin following which the India ink was injected intravenously, resulted in a phagocytosis of a large amount of the injected carbon particles in the endothelial cells of small capillaries. This experiment was repeated by author, but he could not get the same results as those of the authors mentioned above. Therefore he tried intracutaneous injection of histamine on the rabbit's skin instead of painting it, following which the Chinese ink was injected intravenously. Then a characteristic black spot was observed at the histamine injected area. If the skin was removed and examined histologically, the phagocytosis of carbon particles in the endothelial cells of small capillaries, accumulation of them on the cell surface and dilatation of capillaries were observed. And at places where histamine was not injected, he did not observe above described phenomenon. The histamine-induced cellular phagocytic activity was depressed by the pretreatment of intravenous injection of antihistamines. The potency of the antagonistic effect ofantihistamines which was demonstrated in this study was as follows: Pyribenzamine > Benadryl, Decapryn > Antistine.
千葉大学の論文
1954-07-28