Developmental delineation of metabolic-patterns of neonatal mice by using NMR-metabolic profiling on highly-diluted urine

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概要

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• Blood circulation and the route of nutritional supply both change dramatically in the immediate neonatal period. These systemic shifts lead to adjustment of metabolic patterns in the neonate, with alterations in the spectrum of metabolites in body fluids. We have investigated whether ^1H-NMR-based metabolic profiling (NMR-MP) with principal component analysis (PCA) can be used to evaluate metabolite profiles in highly-diluted samples of individual neonatal mouse urine. We report that a 60-fold dilution of urine gave a reproducible NMR-MP analysis. Here the NMR spectral patterns and PCA score plot clearly delineated the developmental changes in urine metabolites in the immediate neonatal period. These results suggest that NMR-MP may offer a powerful method for assessing the physiology and toxicity of chemicals in neonatal periods of experimental animals.

• 日本トキシコロジー学会の論文
• 2009-06-01

著者

• NEMOTO Tadashi

  Biomedicinal Information Research Center, AIST

• Shimizu Yusuke

  Biomedicinal Information Research Center (birc) National Institute Of Advance Industrial Science And

• Nemoto Tadashi

  Biomedicinal Information Research Center (birc) National Institute Of Advance Industrial Science And

• Takahashi Shigeru

  Department Of Pharmacology Tokyo Dental College

• Takahashi Shigeru

  Laboratory Of Environmental Molecular Physiology School Of Life Sciences Tokyo University Of Pharmac

• Sunaga Eri

  Biomedicinal Information Research Center (BIRC), National Institute of Advance Industrial Science an

• Aoyagi Shun

  Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharm

• Kanazawa Kenji

  Biomedicinal Information Research Center (BIRC), National Institute of Advance Industrial Science an

• Takahashi Yuji

  Laboratory of Environmental Molecular Physiology, School of Life Sciences, Tokyo University of Pharm

• Kanazawa Kenji

  Biomedicinal Information Res. Center (birc) National Inst. Of Advance Industrial Sci. And Technol. (

• Kanazawa Kenji

  Biomedicinal Information Research Center (birc) National Institute Of Advance Industrial Science And

• Sunaga Eri

  Biomedicinal Information Research Center (birc) National Institute Of Advance Industrial Science And

• Aoyagi Shun

  Laboratory Of Environmental Molecular Physiology School Of Life Sciences Tokyo University Of Pharmac

• Takahashi Shigeru

  Laboratory Of Applied Entomology College Of Agriculture Utsunomiya University

• Takahashi Yuji

  Laboratory Of Environmental Molecular Physiology School Of Life Sciences Tokyo University Of Pharmac

• Takahashi Yuji

  Laboratory Of Animal Breeding The University Of Tokyo

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