Sesquiterpenes from Cultures of the Basidiomycete Clitocybe conglobata and Their 11β-Hydroxysteroid Dehydrogenase Inhibitory Activity
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概要
- 論文の詳細を見る
A new drimane sesquiterpenoid, 3-keto-drimenol (1), were isolated from cultures of the basidiomycete Clitocybe conglobata together with 3β-hydroxy-11-acetyldrimene (2), 3β-hydroxydrimenol (3), 11,12-dihydroxydrimene (4), 3β-hydroxy-11,12-O-isopropyldrimene (5), and 3β,11,12-trihydroxydrimene (6). Their structures were established from MS and NMR experiments. Compounds 1, 3, and 6 showed inhibitory activities against two isozymes of 11β-hydroxysteroid dehydrogenases with IC_<50> 1.7-8.0μg/ml (human 11β-HSD1), 10.7-24.1μg/ml (mouse 11β-HSD1); 177.0-220.0μg/ml (human 11β-HSD2), 250.5-500.2μg/ml (mouse 11β-HSD2), respectively, which catalyze the interconversion of active cortisol and inactive cortisone.
- 社団法人日本薬学会の論文
- 2009-04-01
著者
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Liu Ji-kai
State Key Laboratory Of Phytochemistry And Plant Resources In West China Kunming Institute Of Botany
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Liu Ji-kai
State Key Laboratory Of Phytochemistry And Plant Resource In West China Kunming Institute Of Botany
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Liu Ji-kai
State Key Lab. Of Phytochemistry And Plant Resources In West China Kunming Inst. Of Botany Chinese A
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Liu Ji-kai
State Key Lab. Of Phytochemistry And Plant Resource In West China Kunming Inst. Of Botany Chinese Ac
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XU Di
State key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botan
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SHENG Yu
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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ZHOU Zhong-Yu
State key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botan
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LIU Rong
State key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botan
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LENG Ying
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Zhou Zhong-yu
State Key Laboratory Of Phytochemistry And Plant Resources In West China Kunming Institute Of Botany
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Xu Di
State Key Laboratory Of Phytochemistry And Plant Resources In West China Kunming Institute Of Botany
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Liu Rong
State Key Laboratory Of Phytochemistry And Plant Resources In West China Kunming Institute Of Botany
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Leng Ying
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Sheng Yu
Shanghai Institute Of Materia Medica Chinese Academy Of Sciences
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Liu Rong
State Key Lab Of Food Science And Technology Institute For Advanced Study Nanchang University
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Xu Di
State Key Laboratory Of Food Science And Technology Nanchang University
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