Single Time Point Isothermal Drug Stability Experiments at Constant Humidity

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概要

• 論文の詳細を見る

• A single time point isothermal drug stability experiments at constant humidity is introduced. In the new method, kinetic parameters related to both moisture and temperature were obtained by a single pair of experiments: these related to moisture by one with a group of testing humidities and a fixed temperature, those related to temperature by the other with a group of testing temperatures and a constant humidity. By a simulation, the estimates for the kinetic parameters (E_a, m, A) obtained by the proposed method and the reported programmed humidifying and heating method were statistically evaluated and were compared with those obtained by the isothermal measurements at constant humidity. Results indicated that under the same experimental conditions, the estimates obtained by the proposed method were significantly more precise than those obtained by the reported programmed humidifying and heating method. The estimates obtained by the isothermal method at constant humidity were somewhat more precise than those obtained by the proposed method. However, the experimental period needed by the isothermal method at constant humidity was greatly longer than that needed by the proposed method. The stability of dicloxacillin sodium, as a solid state model, was investigated by the single time point isothermal drug stability experiments at constant humidity. The results indicated that the kinetic parameters obtained by the proposed method were comparable to those from the reported.

• 公益社団法人日本薬学会の論文
• 2009-03-01

著者

• Zhan Xian-cheng

  Key Lab. Of Drug Targeting West China School Of Pharmacy Sichuan Univ.

• Zhan Xian-cheng

  Key Laboratory Of Drug Targeting West China School Of Pharmacy Sichuan University

• TAO Jian-Lin

  Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University

• LI Lin-Li

  Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University

• LIN Bing

  Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University

• JIANG Lu

  Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University

• Tao Jian-lin

  Key Laboratory Of Drug Targeting West China School Of Pharmacy Sichuan University

• Li Lin-li

  Key Laboratory Of Drug Targeting West China School Of Pharmacy Sichuan University

• Jiang Lu

  Key Laboratory Of Drug Targeting West China School Of Pharmacy Sichuan University

• Lin Bing

  Key Laboratory Of Drug Targeting West China School Of Pharmacy Sichuan University

関連論文

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• Compressed Oxygen in Drug Stability Experiments
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