Compressed Oxygen in Drug Stability Experiments

概要

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A drug stability experiment accelerated by compressed oxygen was established. The stability of 10% ascorbic acid solution as a model was studied and the kinetic parameters were obtained with the newly established experimental method. Because ascorbic acid degrades under both anaerobic and aerobic conditions, the total rate constant k_<total> can be expressed as: k_<total>=k_<anaerobic>+k_<aerobic'> where k_<anaerobic> and k_<aerobic> are the rate constants of anaerobic and aerobic degradations, respectively. The k_<anaerobic> can be expressed as k_<anaerobic>=A_<anaerobic>・exp(-E_<a,anaerobic>/RT) according to Arrhenius equation, and the k_<aerobic> was found to be k_<aerobic>=A_<aerobic>・exp(-E_<a,aerobic>/RT)・P_O_2 in our study.
公益社団法人日本薬学会の論文
2007-01-01