Step Nonisothermal Method in Kinetics Studies of Captopril Oxidation under Compressed Oxygen
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概要
- 論文の詳細を見る
A step nonisothermal experiment under high oxygen pressure and a computation with optimization for a step nonisothermal experiment on a stability study of drugs are introduced. The kinetics parameters of captopril oxidation in aqueous solution were determined with this method. It is reported that the reaction of captopril solution occurs under either aerobic or anaerobic conditions, giving different products. Then the total rate constant ktotai can be expressed as: k_<total>=k_<anaerobic>+k_<aerobic>=A_< anaerobic> exp(-E_<a,anaerobic>/RT)+A_<aerobic> exp(-E_<a, aerobic>/RT)p_<O_2>, where k_<anaerobic> and k_<aerobic> are the rate constants of anaerobic and aerobic degradation, respectively. The results indicate that the parameters obtained in the step nonisothermal experiment are comparable to those obtained in isothermal-isobaric experiments.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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Zhan Xian-cheng
Key Lab. Of Drug Targeting West China School Of Pharmacy Sichuan Univ.
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Zhan Xian-cheng
Key Laboratory Of Drug Targeting West China School Of Pharmacy Sichuan University
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TAO Jian-Lin
Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University
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LI Lin-Li
Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University
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LIN Bing
Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University
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LI Cheng-Rong
Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University
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QI Hai-Jun
Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University
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Tao Jian-lin
Key Laboratory Of Drug Targeting West China School Of Pharmacy Sichuan University
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Li Lin-li
Key Laboratory Of Drug Targeting West China School Of Pharmacy Sichuan University
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Li Cheng-rong
Key Lab. Of Drug Targeting West China School Of Pharmacy Sichuan Univ.
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Lin Bing
Key Laboratory Of Drug Targeting West China School Of Pharmacy Sichuan University
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Qi Hai-jun
Key Laboratory Of Drug Targeting West China School Of Pharmacy Sichuan University
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Li Cheng-rong
Key Laboratory Of Drug Targeting West China School Of Pharmacy Sichuan University
関連論文
- Determination of Phenytoin Sodium Injection and Tablets by Highly Accurate Nephelometric Titration
- Single Time Point Isothermal Drug Stability Experiments at Constant Humidity
- Step Nonisothermal Method in Kinetics Studies of Captopril Oxidation under Compressed Oxygen
- Compressed Oxygen in Drug Stability Experiments