電氣的測定法ニ依ル血球沈降現象ノ研究

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The sedimentation velocity of the red blood corpuscles is estimated with human blood by means of the conductometric method due to M. Suzue, which is based upon the following principle. The red blood corpuscles are practically non-conductive and they decrease, therefore, the conductivity of the blood with the progress of sedimentation, when we employ the special conductivity cell of Suzue's pattern with a pair of electrodes near its bottom. The results obtained are summarized as follows: 1. In cases of healthy men's blood the change of the specific conductivity with the lapse of the time is expressed by the following equation: λ_t=λ_o-At+Bt^2…(1) where t is the time in minutes, λ_o and λ_t are the specific conductivity when the time equals zero initial state) and t respectively, and A and B are the constants The physical meaning of A is the rate of the change of the specific conductivity at t=0, and that of B is the slope of the rate of the change. Employing the method of least squares A and B are calculated as follows: For men A=2.68±0.54 B=0.0083±0.005 For women A=4.45±1.04 B=0.016±0.010 2. The constants A and B with respect to each individuals are calculated also by the method of least squares and are found graphically to be in the linear relation to each other. Hence equation (1) is defined by the two constants, viz., λ_o and A. 3. We define δ_t as δ_t=λ_o-λ_t and for convenience call it the conductivity difference. The relation between δ_<60>'s and A's are found graphically to be linear. Therefore, it is proposed rigorously to adopt δ_<60> as the measure of the change of the specific conductivity, in other words, the sedimentation velocity. δ_<60>'s and their standard deviations in cases of healthy men and women respectively are obtained as follows: For men (131±37.9)×10^<-5>mho. For women (208±71.2)×10^<-5>mho. 4. In most cases of ill person's blood, δ_<60> as well as A are much larger than those of healthy men's blood and in such cases the slope of the rate of the change varies with the lapse of the time, whereas this is not the case with the healthy men's blood. 5. The reproducibility of the change of the specific conductivity is confirmed. 6. The change of the conductivity difference with the lapse of the time goes side by side with the sedimentation velocity estimated by the capillary tube method. The height (mm) of the clear plasma portion according to this method and the conductivity difference, both at t=60, are found graphically to be expressed by the following first order equation: 200m-9δ_<60>-100=0 7. The specific conductivity of the blood at t=O, and the surface tension and the viscosity of the plasma are not related to the conductivity difference at t=60, δ_<60>
京都府立医科大学の論文

電氣的測定法ニ依ル血球沈降現象ノ研究

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