白血球除去療法は全身循環性腸炎惹起性メモリーT細胞を除去する?(<特集>血球成分除去療法の新しい展開)

概要

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Despite the advent of an age when "malignant" leukemia is cured by bone marrow transplantation, "benign" inflammatory bowel diseases (IBDs) are still intractable lifelong diseases. Why is it that once an IBD develops it lasts a long time? We propose that the same mechanism as in the response to vaccination, colitogenic memory CD 4^+ T cells that remember the disease, are formed in IBDs, and, perceived as "benign T-cell leukemia" -like, they spread lifelong pathology that hematogenously throughout the body. In this review, we describe the role of circulating colitogenic CD 4^+ memory T cells on the persistency of IBD in terms of immunological aspects, and propose an idea that leukocytoapheresis, which is widely used for patients with IBD in Japan, blocks such circulation of those cells, and may contribute to its therapeutic effect for the patients.
日本アフェレシス学会の論文
2009-02-28