Saiko-agents, herbal medicines, Kamishoyosan and Saikokeishikankyoto, regulate the plasma interferon-γ (IFN-γ) concentration in the improvement of undefined symptoms in depressed postmenopausal women

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概要

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• Aims: To investigate the effects of herbal medicines, saiko-agents (Saikokeishikankyoto and Kamishoyosan), on the improvement of a depressed mood and on plasma interferon-γ (IFN-γ) concentrations in comparison with those of antidepressants in peri- and postmenopausal women. Methods: Sixty-seven patients complaining of menopausal symptoms including a depressed mood who were diagnosed with mood disorder based on DSM-IV were recruited and divided into two groups (the saiko-agent group was selected on the basis of SHO: 28 cases, antidepressant group: 39 cases), and plasma IFN-γ concentrations were analyzed before and after 1, 2, and 3 months of treatment. Results: There were no significant differences in the decreasing rate of either the climacteric or Hamilton depression score after treatment between the two groups. Plasma IFN-γ concentrations decreased significantly more in the saiko-agent group (-14.3±3.5%) than in the antidepressants group (3.5±1.8%) after 3 months of treatment. A relationship between the rate of the decrease in the climacteric score and plasma IFN-γ (R=0.498, P=0.0056) concentration was observed on treatment with saiko-agents. Conclusion: Saiko-agents, herbal medicines, reduced the plasma IFN-γ concentration related to the improvement of a depressed mood during the treatment in postmenopausal women with undefined symptoms. The findings of the present study indicate that saiko-agents appear to have the potential to decrease morbidity by the alleviation of stress reactions.

著者

• Ushiroyama Takahisa

  Department Of Nursing Aino Gakuin College

• Sakuma Kou

  Department Of Gynecology Aino Hospital

• USHIROYAMA Takahisa

  Department of Nursing,Aino Gakuin College

• SAKUMA Kou

  Department of Gynecology,Aino Hospital

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