The effect of physicians' advice and recommendations on compliance with hormone replacement therapy in the treatment of postmenopausal symptoms in Japanese women : A prospective study

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概要

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• A retrospective study was performed to determine compliance with hormone replacement therapy (HRT), and reasons for discontinuation. This study comprised 477 postmenopausal women who attended the women's psychosomatic and menopause clinic between January 1991 and December 2002. For the purposes of analysis, the postmenopausal women were classified into two groups. In group A (242 subjects), subjects were allowed to decide whether or not to suspend or discontinue the drug, taking their condition into account, after their symptoms were alleviated. In group B (235 subjects), individual women were informed as to the drug's excellent effects on osteoporosis and skin tissue before HRT was started and after their symptoms were alleviated. In group A, the percentage of women who were still on this therapy was 77.7%, 34.3%, 21.1%, and 8.7% at 3, 6, 12, and 24 months, respectively, after the start of therapy. Alternatively, in group B, the 24-month continuation rate was more than 50%. At 36 months (47.2%) and 60 months (38.7%), continuation rates were also significantly higher than those in group A (P<0.0001). The leading reasons concerning the women's decision to discontinue HRT were improvement of symptoms (68.0% and 77.8% in groups A and B, respectively, P=0.408). The incidence of the women's decision to discontinue HRT due to a fear of cancer was significantly higher in group A (10.8%) than in group B (2.8%) (P=0.008). In this study, the key factor affecting HRT compliance proved to be physicians' advice. This means that when HRT is administered to Japanese women with the objective of alleviating menopausal symptoms, high compliance rates can be expected provided individual patients are allowed to decide for themselves when HRT should begin and end.

• 藍野大学の論文

著者

• USHIROYAMA Takahisa

  Department of Obstetrics and Gynecology

• Ushiroyama Takahisa

  Department Of Nursing Aino Gakuin College

• Sakuma Kou

  Department Of Gynecology Aino Hospital

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