Interstitial pneumonia and de-novo onset of asthma induced by leuprorelin acetate for prostate cancer
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概要
- 論文の詳細を見る
We describe herein the first report of side effects induced by leuprorelin acetate (LA) administration. A 70-year-old man, with idiopathic pulmonary fibrosis (IPF), vasospastic angina, diabetes mellitus type 2, and arteriosclerosis obliterans was suffering from prostate cancer. LA administration (drug-) induced interstitial pneumonia based on IPF and the de-novo onset of bronchial asthma, both of which are thought to be Th 2-related diseases. Using 3-color flow cytometry, we analyzed the chemokine receptors CD4+CXCR3+/CD3+ and CD4+CCR4+/CD3+, and found that the CXCR3/CCR4 ratio changed in the Th 2 pattern. It is important to be careful with LA administration, especially for underlying Th 2-related diseases, and clinicians should fully understand the possibilities of LA-inducing de-novo Th 1/Th 2-driven autoimmune diseases.
- 藍野大学の論文
著者
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Nakajima Hideto
First Department Of Internal Medicine Osaka Medical College
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YAMASAKI Hidetomo
Aino Institute for Aging Research
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TANAKA Toshifumi
Aino Institute for Aging Research
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OHSAWA Nakaaki
Aino Institute for Aging Research
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NAKAJIMA Hidito
the First Department of Internal Medicine
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Ohsawa Nakaaki
The Division Of Neurology The First Department Of Internal Medicine Osaka Medical College
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Tanaka Toshifumi
The First Department Of Internal Medicine Osaka Medical College
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- Interstitial pneumonia and de-novo onset of asthma induced by leuprorelin acetate for prostate cancer
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