The leukotriene receptor antagonist montelukast sodium is effective in patients with recurrent bronchodilator-unresponsive chronic dry cough
スポンサーリンク
概要
- 論文の詳細を見る
There have been extremely a few reports regarding the effectiveness of leukotriene receptor antagonist (LTRA) in the treatment of patients with bronchodilatorunresponsive chronic dry cough (BU-CDC). Methods : Research on 12 patients (4 males, 8 females, 9 with atopic factors; age 41±18 yrs) with BU-CDC was carried out to investigate the effects of a 2-week course of the LTRA montelukast sodium (MT) at a dosage of 10 mg once daily. The patients studied had a cough that had persisted for over 4 weeks, which had already failed to be treated with a 2-week course of the β_2-adrenoreceptor agonist. Their response to MT was clinically judged using a cough score (CS). Results: (1) Of the 12 cases studied, 4 cases (33%) showed a good response, 3 (25%) showed a moderate response, and 5 (42%) showed no response. In the total cases, the rate of effectiveness was 58%, and the improvement rate of CS (i-CS) was 28% (P=0.03). (2) The duration of the cough was negatively correlated with the i-CS (r=-0.48, P=0.08), but there was no correlation between the cough severity and the i-CS. (3) Sub-analysis showed that the longer the cough persisted, the poorer the responsiveness was; the i-CS was, 15% in 6 cases with a cough persisting for over 8 weeks, and 40% in 6 cases with a cough persisting for less than 8 weeks (P=0.10). There were no significant differences between the high CS cases and low CS ones, or between the male cases and female ones. Conclusions : MT is effective not only in the treatment of patients with bronchial asthma and cough variant asthma, but also in the treatment of patients with BU-CDC, mostly corresponding to eosinophilic tracheobronchitis with cough hypersensitivity (Fujimura et al) or eosinophilic bronchitis without asthma (Gibson et al).
- 藍野大学の論文
著者
-
YAMASAKI Hidetomo
Aino Institute for Aging Research
-
TANAKA Toshifumi
Aino Institute for Aging Research
-
OHSAWA Nakaaki
Aino Institute for Aging Research
-
Ohsawa Nakaaki
The Division Of Neurology The First Department Of Internal Medicine Osaka Medical College
-
Tanaka Toshifumi
The First Department Of Internal Medicine Osaka Medical College
-
YAMASAKI Hidetomo
Yamasaki Clinic
-
YAMASAKI Keiko
Yamasaki Clinic
-
YAMASAKI Hideki
Yamasaki Clinic
-
Yamasaki Keiko
Yamasaki Clinic : Aino Institute For Aging Research
関連論文
- Interstitial pneumonia and de-novo onset of asthma induced by leuprorelin acetate for prostate cancer
- Magnetic Resonance Imaging and Serum Aldolase Concentration in Eosinophilic Fasciitis
- Longitusinal Study of Serum and Cerebrospinal Fluid (CSF) Class-specific Antibodies against Campylobacter Jejuni and GM1 Ganglioside in Guillain-Barre Syndrome
- Herpes Simplex Virus Type 2 Infections Presenting as Brainstem Encephalitis and Recurrent Myelitis
- Serum Concentrations of Granulocyte Colony-Stimulating Factor (G-CSF) in Antithyroid Drug-Induced Agranulocytosis
- Estrogen Supplementation for Bone Dematuration in Young Epileptic Man Treated with Anticonvulsant Therapy: A Case Report
- Body Height and Weight of Patients with Childhood Onset and Adult Onset Thyrotoxicosis
- Cryofibrinogenemia with Polyarthralgia, Raynaud's Phenomenon and Acral Ulcer in a Patient with Graves' Disease Treated with Methimazole
- Defective Response of Body Height to Growth Hormone Treatment in Resistance to Thyroid Hormone with Short Stature
- Serum Concentrations of Granulocyte Colony-Stimulating Factor (G-CSF) Determined by a Highly-Sensitive Chemiluminescent Immunoassay during the Clinical Course of Subacute Thyroiditis
- Differing Effects of Coping Styles and Personality Traits on Glycemic Control between and within Male and Female Japanese NIDDM Patients
- Introductionof the special lecture of Mrs. Shannon M. Lord
- The leukotriene receptor antagonist montelukast sodium is effective in patients with recurrent bronchodilator-unresponsive chronic dry cough
- The effectiveness of treating patients with recurrent cough variant asthma with leukotriene receptor antagonist montelukast sodium : Clinical parameters concerned with therapeutic responsiveness