The effectiveness of treating patients with recurrent cough variant asthma with leukotriene receptor antagonist montelukast sodium : Clinical parameters concerned with therapeutic responsiveness
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概要
- 論文の詳細を見る
There have been only a few reports regarding the effectiveness of leukotriene receptor antagonist (LTRA) in the treatment of patients with cough variant asthma (CVA). Methods: The present research in patients (9 males, 17 females; age 59±23 yr) with recurrent CVA was performed to investigate the effectiveness of a 2-week course of the LTRA montelukast sodium (MT) based on clinical use of a cough score (CS). Secondly we performed a sub-analysis of clinical parameters for CS, age, and gender in the condition-matched cases drawn from the total cases. Results: Of the 26 cases studied, the course of MT was effective in 19 cases (rate of responsiveness, 73%; 11 cases, good response; 8 cases, moderate response) and induced no response in 7 cases. MT improved the rate of CS by 37±33%, from 4.7 ±2.2 to 3.2±2.5 points (P<0.001). The improvement rate of CS was significantly related to the CS before treatment (r=-0.47, P=0.02). The therapeutic responsiveness was significantly higher in low score cases than high score cases (P=0.03). Cough severity was assumed to be a parameter of therapeutic responsiveness. Significant differences for therapeutic responsiveness were not observed between non elderly and elderly patients, nor between males and females. Conclusions: MT is sufficiently effective in patients with recurrent CVA. In terms of drug compliance, the understanding of inhaled therapy, and complications in the elderly, elderly cases are considered to be active indications for MT therapy. The present study suggests the recommended concomitance of β_2-agonist or inhaled (or oral) corticosteroids with MT in severe cases at the early stage of treatment.
- 藍野大学の論文
著者
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YAMASAKI Hidetomo
Aino Institute for Aging Research
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TANAKA Toshifumi
Aino Institute for Aging Research
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OHSAWA Nakaaki
Aino Institute for Aging Research
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Ohsawa Nakaaki
The Division Of Neurology The First Department Of Internal Medicine Osaka Medical College
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Tanaka Toshifumi
The First Department Of Internal Medicine Osaka Medical College
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YAMASAKI Keiko
Yamasaki Clinic
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YAMASAKI Hideki
Yamasaki Clinic
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TANAKA Toshifumi
Yamasaki Clinic
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Yamasaki Keiko
Yamasaki Clinic : Aino Institute For Aging Research
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