Effects of a Diuretic and Its Combination with Chelating Agent on the Removal of Depleted Uranium in Rats

スポンサーリンク

概要

• 論文の詳細を見る

• We examined the effects of a diuretic, isotonic saline, and chelating agent, catechol-3, 6-bis (methyleiminodiacetic acid) (CBMIDA), on the excretion and prevention of renal damage of depleted uranium (DU). Male Wistar rats (8 weeks old) divided into seven groups were preinjected intraperitoneally with 4mg/kg DU and then the six groups were injected intraperitoneally with a diuretic, a diuretic plus isotonic saline, 480mg/kg or 720mg/kg CBMIDA alone, or 480mg/kg or 720mg/kg CBMIDA plus a diuretic and saline for three days, and the one group was as the control (no treatment). The rats were killed 6 days after DU injection. The results indicated that the diuretic alone and the diuretic with isotonic saline were not effective in removing uranium from the body and protecting the renal function, and also did not help to increase significantly the effects of CBMIDA.

• 日本保健物理学会の論文

著者

• Fukuda Satoshi

  Research and Development Division, Kikkoman Corporation

• YAN Xueming

  Shanghai Institute of Matreial Medica, Chinese Academy of Sciences

• XIE Yuyuan

  Shanghai Institute of Matreia Medica, Chinese Academy of Sciences

• Yan Xueming

  Shanghai Institute Of Materia Medica Shanghai Institutes For Biological Sciences Chinese Academy Of

• Yoshida Hiroki

  Tokyo Nuclear Services Co. Ltd.

• Xie Yuyuan

  Shanghai Institute Of Materia Medica Shanghai Institutes For Biological Sciences Chinese Academy Of

• Ikeda Mizuyo

  Research Center For Radiation Emergency Medicine National Institute Of Radiological Sciences

• NAKAMURA Mariko

  Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences

• Fukuda Satoshi

  Research And Development Division Kikkoman Corporation

• Xie Yuyuan

  Shanghai Inst. Materia Medica Chinese Acad. Sci. Shanghai Chn

• Nakamura Mariko

  Research Center For Radiation Emergency Medicine National Institute Of Radiological Sciences

関連論文

• Antihypertensive and Natriuretic Effects of Less-Sodium Soy Sauce Containing γ-Aminobutyric Acid in Spontaneously Hypertensive Rats
• Effects of a Human Dose of Ca-DTPA on Removal of Plutonium in Rats
• Efficacies of Three Chelating Agents on Removal of Plutonium in Rats : Comparison of CBMIDA, 3,4,3-LIHOPO and Ca-DTPA
• Effects of a Diuretic and Its Combination with Chelating Agent on the Removal of Depleted Uranium in Rats
• Preparation and Characterization of Anti-Fumonisin Monoclonal Antibodies
• Antihypertensive and Natriuretic Effects of Less-Sodium Soy Sauce Containing γ-Aminobutyric Acid in Spontaneously Hypertensive Rats

スポンサーリンク