Effects of a Human Dose of Ca-DTPA on Removal of Plutonium in Rats
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概要
- 論文の詳細を見る
The effects of a daily recommended human dose (1 g per 70 kg body weight= 30 μmol/kg) of calcium diethylentriaminepentaacetic acid (Ca-DTPA) on removal of plutonium from rats injected with different amounts of plutonium were examined. Sixty female wistar rats were preinjected with doses of 0.185, 0.37 and 3.7 × 10^5 Bq/kg of plutonium as a nitrate, and half of the rats of each dose group were injected with 30 μmol/kg of Ca-DTPA for 3 days, beginning 1 h after plutonium injection on the first day. The 24-h urine and feces of rats were collected. The amount of urinary plutonium excretion in the Ca-DTPA groups was found to be significantly greater than that in the respective corresponding control groups at day 1-3. The amount of urinary plutonium excretion in the Ca-DTPA group at the 1st day was increased in response to the plutonium injected dose (correlation coefficient: r = 0.628, vs. r = 0.573 in the control group),that accumulated in the Ca-DTPA group for 3 days was r = 0.800 vs. r = 0.669 in the control group), while their rates of plutonium injected dose were decreased. Such findings were not obtained in the feces measurements. In conclusion, a human dose of Ca-DTPA chelation therapy enhances plutonium excretion as increasing plutonium intake, however the excreted rate of plutonium intake is decreased.
- 日本保健物理学会の論文
著者
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Fukuda Satoshi
International Space Radiation Lab. National Inst. Of Radiological Sciences
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Fukuda Satoshi
International Space Radiat. Lab. Nirs
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Iida H
National Inst. Radiological Sci. Chiba Jpn
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Ida Haruzo
International Space Radiation Lab. National Inst. Of Radiological Sciences
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Iida Haruzo
International Space Radiat. Lab. Nirs
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YAN XUEMING
International Space Radiation Laboratory, National Institute of Radiological Sciences
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YAN Xueming
Shanghai Institute of Matreial Medica, Chinese Academy of Sciences
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Yan Xueming
Shanghai Institute Of Materia Medica Shanghai Institutes For Biological Sciences Chinese Academy Of
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Yan X
Shanghai Inst. Matreia Medica Chinese Acd. Sci. Shanghai Chn
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Iida Haruzo
International Space Radiation Lab. National Inst. Of Radiological Sciences
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